We study mid- and high-level visual processing, specifically links between visual perception, eye movements and neural circuits. We use neurophysiological, psychophysical and computational approaches, combined to improve our understanding of the cortical substrates of natural visually guided behavior (‘natural vision’). Our neurophysiological experiments make extensive use of linear and nonlinear systems identification techniques to characterize single neuron selectivity in striate and extrastriate visual cortex.
In humans, we have developed novel gaze-contingent psychophysical methods to investigate the reference frame or coordinate system used to encoded and sustain spatial attention across saccadic eye movements. This work lies at the intersection of visual attention, working-memory and oculomotor behavior and is intended to explore how all three of these subsystems interact during naturalistic behaviors that depend on eye movements.
Dr. Mazer recieved a PhD in Biology from Caltech in 1995, where he studied the neural substrates of sound localization in barn owls in Dr. Masakazu Konishi's laboratory. He completed postdoctoral training at MIT with Dr. Peter Schiller (1996-1999) and UC Berkeley with Dr. Jack Gallant (1999-2004) where he studied striate and extstriate visual cortex and top-down attentional modulation of feature selectivity during natural vision. He joined the Department of Neurobiology at the Yale School of Medicine in 2004, where he was a professor of Neurobiology and Psychology until 2016. In 2016 he moved to Bozeman, Montana to join the Department of Cell Biology and Neuroscience at Montana State University.
- NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex, Wang M., Yang, Y. Wang, C-J, Gamo, N.J., Jin, L.E., Mazer, J.A., Morrison, J. H., Wang, X-J, Arnsten, A.F.T., Neuron, 77(4):736-749,2013. Mazer, J. A., Biological Psych., 69(12):1147-52, 2011.
- Attention doesn’t slide: spatiotopic updating after eye movements instantiates a new, discrete attentional locus, Golomb, JD, Marino, AC, Chun, MM, Mazer, JA, Attention, Perception & Psychophysics, 73(1):7-14, 2011
- Attentional facilitation throughout human visual cortex lingers in retinotopic coordinates after eye movements, Golomb, JD, Pguyen-Phuc, AY, Mazer, JA, McCarthy, G, Chun, MM, Journal of Neuroscience, 2010 Aug 4
- Robustness of the retinotopic attentional trace after eye movements, Golomb, JD, Pulido, VZ, Albrecht, AR, Chun, MM Mazer, JA. J. of Vision, 2010 Mar 31;10(3):19.1-12.
- The native coordinate system of spatial attention is retinotopic. Golomb JD, Chun MM, Mazer JA. J Neurosci. 2008 Oct 15;28(42):10654-62.
- Attention to stimulus features shifts spectral tuning of V4 neurons during natural vision. David SV, Hayden BY, Mazer JA, Gallant JL. Neuron. 2008 Aug 14;59(3):509-21.
- Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. Cell. 2007 Apr 20;129(2):397-410.
- Goal-related activity in V4 during free viewing visual search. Evidence for a ventral stream visual salience map. Mazer JA, Gallant JL. Neuron. 2003 Dec 18;40(6):1241-50.
- A human extrastriate area functionally homologous to macaque V4. Gallant JL, Shoup RE, Mazer JA. Neuron. 2000 Aug;27(2):227-35.